Methylation

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Epigenetic methylation events are heritable modifications that regulate gene expression without altering the DNA sequence itself. They serve as regulatory mechanisms for a wide range of biological processes and genetic diseases, and irregular methylation patterns have been correlated with certain cancers. Methylation microarrays facilitate global investigation of regulatory events, in vivo, without the limitations of gene-specific analyses or the hands-on time required by chromatography-based methods.

Agilent

Agilent offers DNA methylation technology for biological research. The microarrays allow the monitoring of methylation events within CpG Islands, near promoters of human and mouse genomes, or defined regions such as those found in ENCODE .Click here for more

Sample Requirements: 5ug gDNA (includes MeDIP)

Illumina

>> Infinium Methylation

Powered by Illumina’s revolutionary Infinium Assay, the HumanMethylation27 DNA Analysis BeadChip allows researchers to interrogate 27,578 highly informative CpG sites per sample at single-nucleotide resolution. Click here for more

Sample Requirements: 500ng-1ug gDNA (with bisulphite conversion)