How the unique expertise of the LAGA can benefit your research

LAGA’s expertise is unique due to the combination of advanced analytical tools and computer science methods applied to genomics technologies. LAGA’s expertise provides your research projects with the following competitive advantages:

1. Translational research: genomics research applied to disease management and biological endpoints.
2. A combination of array- and NGS-based technologies with advanced bioinformatics capabilities to analyze high density genomic and transcriptome information.
3. Expertise in nucleic acid preparation from standard and FFPE specimens.
4. Support of all array-based applications.
5. Ability to integrate, visualize and analyze all available data types, including those from technologies not directly supported by LAGA - i.e. Affymetrix and MIP.
6. Biostatistical analyses (power calculation, logistic regression modeling, ROC analysis, Kaplan Meier estimator, ANOVA on slopes from linear regression analysis, Cox proportional hazards model, principal component analysis).
7. Extensive expertise for analysis of NGS data, both genomic and RNA - mapping, copy number analysis, identification of fusion genes, splice isoforms.
8. Ability to perform exon-level analysis of multiple samples profiled both by array and RNA-Seq for a truly comprehensive view of the transcriptome, including mutation expression levels and global changes in splicing patterns.
9. Tools and expertise for integrating clinical information with expression/genomic data.
10. Prototyped pipeline for development of predictive markers of drug response
11. Pipelines for analysis of large gene lists (i.e. of differentially expressed and mutated genes): Ingenuity pathway mapping, GO enrichment analysis
12. Ability to rapidly develop novel analysis tools as required by the customer’s project, such as Brown and UCSF.

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